Objectives: To determine the risk factors for the development of chronic rejection beyond 1 year in patients with good renal function at the end of the lst year post-transplantation.
Patients and Methods: Between June 1984 and Dec. 1991, 880 renal transplantations were done in our center, had been entered into our database. 505 patients were survived 1 year and had good renal function(serum creatinine less than 2.0 mg%, no proteinuria and no microscopic hematuria at the end of the Ist year). Among 505 patients we could draw out two different patient populations. Group A(N=430): patients with good renal function(current serum creatinine less than 130% of serum creatinine at 1 year, no proteinuria and no microscopic hematuria) during follow up. Group B(N=75$ patients with biopsy-proven chronic rejection during follow up after i year posttransplantation. Between.two groups, 12 variables; transplantation number, age, gender, degree of HLA matching(DHM), acute rejection within 1 year(AR-1), early rejection within 1 week(ER-1), kinds of CsA protocol, ABO matching, infection episodes(IE), relationship(RS), CsA dosage & blood level at the end of 1 year(CsD-1 & CsL-1) were compared.
Result: No significant risk factor for chronic rejection was found; p value for ER-1, AR-1, IE, CsD-1 and CsL-1 were over 0.05.
Conclusion: Previously reported risk factors for chronic rejection(AR-1, CsD-1, IE) were found to be not significant in this study. Well-treated acute rejection or infectious episodes is no longer considered high risk group for the development of chronic rejection during follow up.
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